| 1st Qualifying Round | 2nd Qualifying Round | 3rd Qualifying Round | Play-offs | Group Stage | Round of 16 |
| Quarterfinals | Semifinals | Final |
Rodada:
Jogados
1ª Rodada
15/09/2021 - Quarta
09:45
Beşiktaş
1
x
2
Borussia Dortmund
12:00
Sporting CP
1
x
5
Ajax
2ª Rodada
28/09/2021 - Terça
09:45
Ajax
2
x
0
Beşiktaş
12:00
Borussia Dortmund
1
x
0
Sporting CP
3ª Rodada
19/10/2021 - Terça
09:45
Beşiktaş
1
x
4
Sporting CP
12:00
Ajax
4
x
0
Borussia Dortmund
4ª Rodada
03/11/2021 - Quarta
13:00
Borussia Dortmund
1
x
3
Ajax
13:00
Sporting CP
4
x
0
Beşiktaş
5ª Rodada
24/11/2021 - Quarta
09:45
Beşiktaş
1
x
2
Ajax
12:00
Sporting CP
3
x
1
Borussia Dortmund
6ª Rodada
07/12/2021 - Terça
12:00
Ajax
4
x
2
Sporting CP
12:00
Borussia Dortmund
5
x
0
Beşiktaş